some evidence now

Although there is some evidence now that the prognosis of RA has improved, possibly thanks to better medical care and especially the early introduction of disease modifying therapy, there is no doubt that it continues to exist today.

Day a group of patients with a highly disabling disease. It is what we would call RA serious (aggressive according to the Anglo-Saxon terminology Keto Viante) and that Young and Van der Heijde define «as that disease of rapidly progressive clinical course that affects multiple joints with little or no response to drugs modifying the disease and marked disability, resulting in loss of work and / or dependence on others ».